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3-Butene-1,2-diol: An attractive precursor for the synthesis of enantiomerically pure organic compounds

✍ Scribed by AV Rama Rao; D Subhas Bose; M.K. Gurjar; T Ravindranathan

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 535 KB
Volume: 45
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)89171-7

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✦ Synopsis

3-Butene-I,2-diol obtained by the isomerlzatlon of cls-butene-1,4-dlol has been transformed into several choral bulldmg blocks. Small and polyfunctlonal chiral bullding blocks form a backbone of research in the area of natural product chemistry. lntroductlon of new choral building blocks with a wide range of apphcatlons or synthetic modlflcatlon of exlstmg proven molecules are currently undergomg intensive studies'. A large number of such molecules have been derived from naturally occurrmg compounds hke carbohydrates, ammo acids or hydroxy acids alblet in relatively long synthetic sequences. However, stereocontrolled asymmetrlc constructlon of these molecules with one or more asymmettlc centers could be effected with a shorter synthetic pathway2. A. V. bMA km et al.

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