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3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A New Scaffold for the Selective Inhibition of Monoamine Oxidase B

✍ Scribed by Maccioni, Elias; Alcaro, Stefano; Cirilli, Roberto; Vigo, Sara; Cardia, Maria Cristina; Sanna, Maria Luisa; Meleddu, Rita; Yanez, Matilde; Costa, Giosuè; Casu, Laura; Matyus, Peter; Distinto, Simona


Book ID
118233911
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
837 KB
Volume
54
Category
Article
ISSN
0022-2623

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## Abstract Reaction of 2,4‐diaryl‐2,3‐dihydro‐1,5‐benzothiazepines 1 with a mixture of acetic anhydride and pyridine afforded 3‐acetyl‐2,3‐dihydrobenzothiazoles 2 as sole products in good yields. Stereochemistry and the hindered rotation of the amide group were studied by means of NMR spectroscopy