✦ LIBER ✦
3-(4-iodomethyl-2-oxo-1-azetidinyl)propynoic acidt-butyl ester: a new β-lactam derivative, synthesis of an ynamide by reaction of 4-iodomethylazetidin-2-one with the t-butyl ester of propiolic acid in the presence of copper(i)
✍ Scribed by Aldo Balsamo; Bruno Macchia; Franco Macchia; Armando Rossello; Paolo Domiano
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 260 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The reaction of 4-iodomethylazetidin-2-one ( 2) with the t-butyl ester of propioZic acid (4) in the presence both of equimolar amounts of copper(I) and oxygen results unexpected-Zy in the formation of the $-Zactum ynamide 5. Its structure was suggested by spectroscopic data and confirmed by singLe-crystal X-ray analysis.