A simple pmcedure is described for the pqaration of 3-0x0-1.2,~~thiadbzoles under mild conditions. Thii procedure has provided hitherto unknown 7fL[3-ox~k1,2,5-tii1-2-y1] cephalosporins. N-Sulfinylamines, 1, have been shown to offer considerable synthetic opportunities.1~2~3 They have often been pre
โฆ LIBER โฆ
3-[(1,2,3-Thiadiazol-5-ylthio)methyl]cephalosporins
โ Scribed by Lewis, Graham S.; Nelson, Peter H.
- Book ID
- 121252023
- Publisher
- American Chemical Society
- Year
- 1979
- Tongue
- English
- Weight
- 709 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
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The title compound, C~12~H~9~N~5~O~3~S~2~, was synthesized __via__ condensation of 1,2,4-oxadiazole chloromethane with 1,3,4-thiadiazolethiol. The benzene and oxadiazole rings are almost coplanar, making a twist angle of only 4.6โ (3)ยฐ, but the thiadiazole ring deviates from the molecular plane, maki