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(+)-(2S,3S,4S,5S)-3-[3,5-Bis(trifluoromethyl)benzyloxy]-N-(tert-butoxycarbonyl)-4,5-dimethyl-2-phenylpyrrolidine, (I), and (+)-(2S,3S,4S,5S)-3-[3,5-bis(trifluoromethyl)benzyloxy]-4,5-dimethyl-2-phenylpyrrolidinium p-toluenesulfonate, (II), at 134K

โœ Scribed by Bats, J. W. ;Heinrich, T. ;Reggelin, M.


Book ID
119771184
Publisher
International Union of Crystallography
Year
1999
Tongue
English
Weight
268 KB
Volume
55
Category
Article
ISSN
0108-2701

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Stereoselective synthesis of 2-(S)-(3,5-
โœ Michael S. Ashwood; Ian F. Cottrell; Antony J. Davies ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 370 KB

A convenient process for the preparation of the secondary amine 6, 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-l,4-oxazine, is described starting from the readily available (S)-phenylglycine 1. The process features efficient construction of the homochiral oxazinone intermediate 3 and ster