Stereoselective synthesis of 2-(S)-(3,5-
โ
Michael S. Ashwood; Ian F. Cottrell; Antony J. Davies
๐
Article
๐
1997
๐
Elsevier Science
๐
English
โ 370 KB
A convenient process for the preparation of the secondary amine 6, 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-l,4-oxazine, is described starting from the readily available (S)-phenylglycine 1. The process features efficient construction of the homochiral oxazinone intermediate 3 and ster