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2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1

✍ Scribed by Qian-fen Gong; E-hu Liu; Rong Xin; Xiuning Huang; Ning Gao

Publisher
Springer
Year
2011
Tongue
English
Weight
586 KB
Volume
352
Category
Article
ISSN
0300-8177

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## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia