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2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc

✍ Scribed by William Perea; Marco Cannella; Jun Yang; Alexander J. Vega; Tatyana Polenova; Michele Marcolongo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
505 KB
Volume
57
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Deuterium (^2^H) double‐quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build‐up rates, and DQF‐detected rotating‐frame spin‐lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and display a monotonous correlation with age between 15 and 80 years. The implications of this work are that the changes in water dynamics as detected via DQF NMR spectroscopy may be used as a probe of tissue degeneration in NP, particularly in the early stages of degeneration to which most standard NMR methods are not sensitive. Magn Reson Med 57:990–999, 2007. © 2007 Wiley‐Liss, Inc.

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