2D J-resolved spiral spectroscopic imaging at 7 T: Application to mobile lipid mapping in a rat glioma
✍ Scribed by Bassem Hiba; Raphaël Serduc; Peggy Provent; Régine Farion; Chantal Rémy; Anne Ziegler
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 360 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Lactate (Lac) and mobile lipids (Lip), which are present in rat gliomas, are difficult to map because their ^1^H resonances overlap in the 1.3 ppm region. 2D __J‐__resolved spectroscopy enables proper separation of the two resonance lines. To obtain high‐spatial‐resolution mapping of Lac and Lip resonances within a reasonable experiment time, we coupled 2D __J‐__resolved spectroscopy with a fast spectroscopic imaging (SI) method, based on an out‐and‐in spiral k‐space description. The method was applied to a rat glioma at 7 T, and Lac and Lip maps were reconstructed. The duration of SI (2D spatial, 2D spectral) was 64 min for a theoretical in‐plane resolution of 1 × 1 mm, and a slice thickness of 2 mm (voxel size 8.2 μl, taking into account the point‐spread function (PSF)). Magn Reson Med 52:658–662, 2004. © 2004 Wiley‐Liss, Inc.