2966. Acrylonitrile metabolism: Gut, I., Nerudová, J., Kopecký, J. & Holecěk, V. (1975). Acrylonitrile biotransformation in rats, mice, and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate. Arch. Tox. 33, 151

Acrylonitrile biotransformation in rats,

Acrylonitrile biotransformation in rats, mice, and chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate

✍ I. Gut; J. Nerudová; J. Kopecký; V. Holeček 📂 Article 📅 1975 🏛 Springer-Verlag 🌐 English ⚖ 733 KB

Female Wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrilc, indicated a decreasing proportion of biotransformation after oral (