28 Up-regulation of P21(WAF1/CIP1) CDKI gene in chronically rejected renal allografts
β Scribed by A. Chkhotua; A. Altimari; E. Gabusi; L. Managadaze; S. Stefoni; A. Yussim; W.F. Grigioni
- Book ID
- 118645244
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 201 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1569-9056
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π SIMILAR VOLUMES
WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet
## Abstract The cyclinβdependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30β60βmin independent of new protein synthesis in the estrogen recept