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279. Antitumor activity of native and glycated fibrinogen-methotrexate conjugates

✍ Scribed by D. Nevozhay; M.S. Omar; A. Nasulewicz; U. Kańska; J. Wietrzyk; A. Opolski; J. Boratyński

Book ID
104441359
Publisher
Wielkopolskie Centrum Onkologii
Year
2003
Tongue
Polish
Weight
204 KB
Volume
8
Category
Article
ISSN
1507-1367

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Antitumor activity of methotrexate-album
Antitumor activity of methotrexate-albumin conjugates in rats bearing a Walker-256 carcinoma
✍ Andreas Wunder; Gerd Stehle; Hans Herrmann Schrenk; Gernot Hartung; Dieter Ludwi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 159 KB

We have recently reported that albumin accumulates in solid tumors and serves there as a source of nitrogen and energy. Methotrexate-albumin conjugates [MTX( 1)-RSA] derivatized at a molar ratio of 1:1 differ favorably from original MTX in terms of plasma presence and tumor uptake. The purpose of th