267. Resorption, Retention, Verteilung und Stoffwechsel des d, l-α-Tocopheramins, d, l-N-Methyl-γ-tocopheramins und des γ-Tocopherols im Vergleich zum d,l-α-Tocopherol bei der Ratte
✍ Scribed by U. Gloor; J. Würsch; U. Schwieter; O. Wiss
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- German
- Weight
- 683 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
The synthesis of a number of tocopheramines and N-alkyl-tocopheramines is described. The biological activity of the tocopheramines in the hemolysis test is shown to be similar to that of the corresponding tocopherols. N-Methylation ha? a varying influence. In the case of d, I-a-tocopheramine, the biological activity is reduced to less than a tenth by monomethylation, with d,l-B-and d,I-y-tocopheramine however it is increased about fivefold and even surpasses the biological activity of d,Z-atocopherol. N-Dimethylation leads in all cases to inactivation. N-Monoinethyl-d, 1y-tocopheramine was found to be inactive or at least much less active than the Nmonomethyl derivative.
Forschungsabteilung der I?. HOFFMANN-LA ROCHE & Co. AG., Base1 LITERATURVERZEICHNI S