263 REGULATION OF MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 AND 5-LIPOXYGENASE-ACTIVATING PROTEIN/5-LIPOXYGENASE BY 4-HYDROXYNONENAL IN OSTEOARTHRITIC CHONDROCYTES

Regulation of the expression of 5-lipoxy

Regulation of the expression of 5-lipoxygenase–activating protein/5-lipoxygenase and the synthesis of leukotriene B4 in osteoarthritic chondrocytes: Role of transforming growth factor β and eicosanoids

✍ Johanne Martel-Pelletier; François Mineau; Hassan Fahmi; Stefan Laufer; Pascal R 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 1 views

## Abstract ## Objective To explore the modulation of 5‐lipoxygenase–activating protein (FLAP) and 5‐lipoxygenase (5‐LOX) expression in human osteoarthritic (OA) chondrocytes, their relative implications in leukotriene B~4~ (LTB~4~) production, the effect of different factors on this system, and t