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254 Age-related changes in blood-brain barrier (BBB) on senescence accelerated mouse (SAM)

✍ Scribed by M. Ueno; M. Shinnou; H. Sakamoto; I. Akiguchi; M. Hosokawa; A.W. Vorbrodt

Book ID: 118577948
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 132 KB
Volume: 17
Category: Article
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(96)80256-9

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Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of system