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2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles

โœ Scribed by Thomas J. Delia; Dennis P. Anderson; Jennifer M. Schomaker

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
30 KB
Volume
41
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Abstract

In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6โ€trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6โ€trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2โ€substitution with ammonia and ethanolamine while aniline gave the 4โ€substituted derivative as the preferred product.

๐Ÿ“œ SIMILAR VOLUMES

Reactions of tetrachloropyridazine with
Reactions of tetrachloropyridazine with aliphatic nitrogen nucleophiles
โœ Graham Pattison; Graham Sandford; Emma V.B. Wallace; Dmitry S. Yufit; Judith A.K ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 366 KB

## Abstract magnified image Nucleophilic aromatic substitution reactions of tetrachloropyridazine with a series of aliphatic primary and secondary amines led selectively to products arising from replacement of chlorine at the 4โ€position in all cases. The structures of the products were unambiguous