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246 NOTCH SIGNALING PATHWAY REGULATES P57KIP2 EXPRESSION IN HUMAN HEPATOCELLULAR CARCINOMA

✍ Scribed by M. Minguzzi; C. Giovannini; F. Fornari; L. Gramantieri; P. Chieco; L. Bolondi


Book ID
117377256
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
49 KB
Volume
50
Category
Article
ISSN
0168-8278

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Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and