246 EXPRESSION OF P53R2 IN CHONDROCYTES IS REGULATED BY SHEAR STRESS
β Scribed by K. Kawakita; T. Nishiyama; T. Fujishiro; S. Hayashi; N. Kanzaki; K. Takebe; M. Kurosaka
- Book ID
- 114352027
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 58 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1063-4584
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## Abstract Onset and progression of cartilage degeneration is associated with shear stress occurring in diarthrodial joints subjected to inappropriate loading. This study tested the hypothesis that shear stress induced nitric oxide is associated with altered expression of regulatory oncoβproteins,
Transgenic mice were produced harboring the p53 murine cDNA clone regulated by the SV40 enhancer-promoter region 5' to the cDNA and the small t antigen splice sites, and poly(A) addition signals 3' to the cDNA. This construction was not expressed in these mice. The presence of several murine p53 int