2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

Acute toxicity study of 1,3,3,5,5-pentaz

Acute toxicity study of 1,3,3,5,5-pentaziridino-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide (a new antitumor agent with an inorganic ring) in mice, rats and dogs

✍ Shigeki Nakano; Kazumasa Yamashita; Yoshinobu Kirihara; Masahiko Kuwata; Ken'ich 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 689 KB

In order to study the safety of 1,3,3,5, 5-pentaziridino-l-thia-2,4,6-triaza-3,5-diphosphorine-l-oxide (SOAz), a new antitumor agent, acute toxicity studies by intravenous administration were performed in ddY mice, Wistar rats and beagle dogs. The LDso values in rodents were 325 mg kg-' for male mic