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2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256

✍ Scribed by L.M. Cobb; T.A. Connors; L.A. Elson; A.H. Khan; B.C.V. Mitchley; W.C.J. Ross; M.E. Whisson


Book ID
115770207
Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
730 KB
Volume
18
Category
Article
ISSN
0006-2952

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Studies on the mechanism of action of 5-
✍ T. A. Connors; D. H. Melzack πŸ“‚ Article πŸ“… 1971 πŸ› John Wiley and Sons 🌐 French βš– 470 KB

## Abstract CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large number of other animal tumours. A line of the Walker tumour with acquired resistance to CB 1954 was cross‐resistant to Melphalan, implying a common mechanism