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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced changes in activities of nuclear protein kinases and phosphatases affecting DNA binding activity of c-Myc and AP-1 in the livers of guinea pigs

โœ Scribed by Hitoshi Ashida; Scott Nagy; Fumio Matsumura


Book ID
113994714
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
733 KB
Volume
59
Category
Article
ISSN
0006-2952

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To study the long-term effect of 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) on the DNAbinding activity of nuclear transcription factors; a single dose of TCDD was injected intraperitoneally to male guinea pigs (1 lg/kg i.p.). The animals were killed after 1, 2, 10, 20, 28, and 40 days, and DNA-bindin