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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T-cell development in mice

✍ Scribed by Katarina Lundberg; Kjell-Olov Grönvik; Tom J. Goldschmidt; Lars Klareskog; Lennart Dencker

Book ID: 113137336
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 785 KB
Volume: 74
Category: Article
ISSN: 0009-2797
DOI: 10.1016/0009-2797(90)90066-v

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To understand the basic mechanisms of TCDD's action to cause hypoinsulinemia in several experimental animals, we have studied TCDD-induced changes in various protein kinase activities in membrane preparations of guinea pig pancreas. For this purpose, young male guinea pigs were treated through a sin