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234 Fine tuning of receptor-selectivity for TNF using a phage display system with one-step competitive-subtractive panning

✍ Scribed by Yasuhiro Abe; Hiroko Shibata; Tetsuya Nomura; Hiroyuki Kayamuro; Yohei Mukai; Tomoaki Yoshikawa; Yasuo Yoshioka; Madoka Taniai; Tsunetaka Ohta; Shinsaku Nakagawa; Haruhiko Kamada; Shin-ichi Tsunoda; Yasuo Tsutsumi

Book ID: 116398521
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 53 KB
Volume: 43
Category: Article
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2008.07.298

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Tumor necrosis factor-a (TNF) is one of the attractive targets for the development of anti-inflammatory and anti-tumor drugs, because it is an important mediator in the pathogenesis of several inflammatory diseases and tumor progression. Thus, there is an increasing need to understand the TNF recept