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2,3-Diarylthiophenes as Selective EP1 Receptor Antagonists.

โœ Scribed by Yves Ducharme; et al. et al.


Publisher
John Wiley and Sons
Year
2005
Weight
26 KB
Volume
36
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Naphthalene/quinoline amides and sulfony
โœ Jason D. Burch; Julie Farand; John Colucci; Claudio Sturino; Yves Ducharme; Rich ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 755 KB

Two new series of EP(4) antagonists based on naphthalene/quinoline scaffolds have been identified as part of our on-going efforts to develop treatments for inflammatory pain. One series contains an acidic sulfonylurea pharmacophore, whereas the other is a neutral amide. Both series show subnanomolar