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229 EFFECT OF TREATMENT WITH THE CATHEPSIN-K INHIBITOR, BALICATIB, ON CARTILAGE VOLUME AND BIOCHEMICAL MARKERS OF BONE AND CARTILAGE DEGRADATION IN PATIENTS WITH PAINFUL KNEE OSTEOARTHRITIS

✍ Scribed by D. Manicourt; A. Beaulieu; P. Garnero; C. Peterfy; F. Bouisset; S. Haemmerle; L. Mindeholm


Book ID
114350377
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
43 KB
Volume
15
Category
Article
ISSN
1063-4584

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## Abstract ## Objective Bisphosphonates have slowed the progression of osteoarthritis (OA) in animal models and have decreased pain in states of high bone turnover. The Knee OA Structural Arthritis (KOSTAR) study, which is the largest study to date investigating a potential structure‐modifying OA