2.231 ADX48621, A MGLUR5 NEGATIVE ALLOSTERIC MODULATOR ALLEVIATES L-DOPA-INDUCED CHOREA AND DYSTONIA IN THE MPTP MACAQUE MODEL OF PARKINSON'S DISEASE

Histamine H3 receptor agonists reduce L-

Histamine H3 receptor agonists reduce L-dopa–induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease

✍ Jordi Gomez-Ramirez; Tom H. Johnston; Naomi P. Visanji; Susan H. Fox; Jonathan M 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB 👁 1 views

## Abstract L‐dopa–induced dyskinesia (LID) remains a major complication of the treatment of Parkinson's disease. The neural mechanisms underlying LID are thought to involve overactivity of striatal glutamatergic neurotransmission, with resultant underactivation of the output regions of the basal g