To determine if some individuals with deforming varieties of osteogenesis imperfecta (OI) carry point mutations in the COL1A2 gene of type-I collagen, we examined collagens synthesized by cell strains from affected individuals for the presence of cysteine in the triple helical domain of the alpha 2
2,2,2-Trifluoroethanol disrupts the triple helical structure and self-association of type I collagen
β Scribed by Shanmugam, Ganesh; Reddy, Samala Murali Mohan; Natarajan, Venkatachalam; Madhan, Balaraman
- Book ID
- 122438167
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 517 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0141-8130
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π SIMILAR VOLUMES
Collagen biosynthesis is a complex process that begins with the association of three procollagen chains. A series of conserved intra-and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucle
## Clinical Data on Patients KO was 35 years of age at the time her cell strain was sent to us. She was born to healthy unrelated parents and has two healthy siblings, both of whom have unaffected children, and no other individuals with 0 1 were identified in the family. She had many fractures at