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221 FUNCTIONAL ANALYSIS OF A RARE MUTATION OF MITOCHONDRIAL DNA FOUND IN A PROSTATE CANCER

โœ Scribed by Arnold, Rebecca; Osunkoya, Adeboye; O'Hearn, Sean; Marshall, Fray; Wallace, Douglas; Yi, Hong; Wright, Elizabeth; Sun, Carrie; Costello, Les; Petros, John


Book ID
123540038
Publisher
Lippincott Williams and Wilkins
Year
2010
Tongue
English
Weight
42 KB
Volume
183
Category
Article
ISSN
0022-5347

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DNA polymerase ฮฒ is essential for short-patch base excision repair. We have previously identified 20 somatic pol ฮฒ mutations in prostate tumors, many of them missense. In the current article we describe the effect of all of these somatic missense pol ฮฒ mutations (p.K27N, p.E123K, p.E232K, p.P242R, p