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221 FER Kinase Promotes Breast Cancer Growth and Metastasis by Regulating Cell Adhesion and Migration

✍ Scribed by I.A. Ivanova; J.F. Vermeulen; C. Ercan; J.M. Houthuijzen; F. Al Saig; E. van der Wall; P.J. van Diest; M. Vooijs; P.W.B. Derksen

Book ID
117662753
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
55 KB
Volume
48
Category
Article
ISSN
0959-8049

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Syk, a nonreceptor type of protein tyrosine kinase widely expressed in hematopoietic cells, is a candidate suppressor gene in human breast cancer. Reduced expression of Syk protein is correlated with poor prognosis, while its overexpression can reduce the malignant phenotype of breast cancer cells.