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2.2 å resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains)

✍ Scribed by Torsten Unge; Stefan Knight; Rama Bhikhabhai; Seved Lövgren; Zbigniew Dauter; Keith Wilson; Bror Strandberg


Book ID
114329348
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
1017 KB
Volume
2
Category
Article
ISSN
0969-2126

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rac-2-Cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047) is a potent inhibitor of HIV-1 multiplication in acutely infected cells. MC-1047 racemate has been resolved by chiral HPLC using, as chiral stationary phase (CSP), a commercially available (R,R)-W