## Abstract In contrast to earlier reported unsuccessful experiments the Michael addition of prop‐2‐enal to 2‐methylcyclopentane‐1,3‐dione (1) affords 3‐(1‐methyl‐2,5‐dioxocyclopentyl)propanal (3) in 90% yield, if the reaction is carried out in water without a basic catalyst. This aldehyde is conve
✦ LIBER ✦
2,2-Disubstituted Cyclopentane-1,3-diones. Part 5. Simple Procedures for the Preparation of Racemic (1RS,5RS)-5-Methyl-2-oxabicyclo[3.3.0]octane-3,6-dione Starting from 2,2-Disubstituted Cyclopentane-l,3-diones
✍ Scribed by Prof. Dr. H. Schick; Chemieingenieur S. Ballschuh; Chemieingenieur H.-P. Welzel; Prof. Dr. S. Schwarz
- Book ID
- 105353936
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 541 KB
- Volume
- 333
- Category
- Article
- ISSN
- 1615-4150
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The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools. IMPDH exists as 2 isoforms, one of which is induced in tumor cells, type II and thus