𝔖 Bobbio Scriptorium
✦   LIBER   ✦

22 Determinants of RAF Inhibitor Resistance

✍ Scribed by Solit, D.

Book ID
122575530
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
56 KB
Volume
48
Category
Article
ISSN
0959-8049

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Resistance to RAF Inhibitors Revisited
Resistance to RAF Inhibitors Revisited
✍ Hartsough, Edward; Shao, Yongping; Aplin, Andrew E πŸ“‚ Article πŸ“… 2014 πŸ› Nature Publishing Group 🌐 English βš– 363 KB
RAF inhibitor resistance is mediated by
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
✍ Poulikakos, Poulikos I.; Persaud, Yogindra; Janakiraman, Manickam; Kong, Xiangju πŸ“‚ Article πŸ“… 2011 πŸ› Nature Publishing Group 🌐 English βš– 716 KB

Activated RAS promotes dimerization of members of the RAF kinase family . ATP-competitive RAF inhibitors activate ERK signalling 4-7 by transactivating RAF dimers . In melanomas with mutant BRAF(V600E), levels of RAS activation are low and these drugs bind to BRAF(V600E) monomers and inhibit their a

The Yin-Yang of RAF inhibitors
The Yin-Yang of RAF inhibitors
✍ Ha Linh Vu; Andrew E. Aplin πŸ“‚ Article πŸ“… 2012 πŸ› Wiley (Blackwell Publishing) 🌐 English βš– 62 KB