213 HEPATOCELLULAR CARCINOMA PROGRESSION IS ACCELERATED BY CANCER-ASSOCIATED FIBROBLASTS STIMULATED BY TUMOR PRODUCTION OF LYSOPHOSPHATIDIC ACID

Tumor-secreted lysophostatidic acid acce

Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts

✍ Antonio Mazzocca; Francesco Dituri; Luigi Lupo; Michele Quaranta; Salvatore Anto 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 980 KB

Hepatocellular carcinoma (HCC) occurs in fibrotic liver as a consequence of underlying cirrhosis. The goal of this study was to investigate how the interaction between HCC cells and stromal fibroblasts affects tumor progression. We isolated and characterized carcinoma-associated fibroblasts (CAFs) a