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2.112 DJ-1 regulation of p53 pathway and its impairment by Parkinson's disease-associated mutations

✍ Scribed by E. Giaime; C. Sunyach; H. Ariga; M. Goldberg; J. Shen; P. Heutink; F. Checler; C. Alves da Costa


Book ID
117752844
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
53 KB
Volume
13
Category
Article
ISSN
1353-8020

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN