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210 LOSS OF CHROMOSOME 3P IN CLEAR CELL RENAL CELL CARCINOMA – ARE THERE DIFFERENCES ACCORDING TO THE UNDERLYING ABERRATION?

✍ Scribed by Klatte, Tobias; Rao, Nagesh; de Martino, Michela; Shuch, Brian; Zomorodian, Nazy; Said, Jonathan; Kabbinavar, Fairooz; Belldegrun, Arie; Pantuck, Allan

Book ID
123256334
Publisher
Lippincott Williams and Wilkins
Year
2010
Tongue
English
Weight
42 KB
Volume
183
Category
Article
ISSN
0022-5347

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Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1