21 LOAD-INDUCED PROGRESSIVE LESIONS ARE ASSOCIATED WITH PROTEOGLYCAN LOSS BUT NOT WITH CELL DEATH

Transforming growth factor-β1 induces ap

Transforming growth factor-β1 induces apoptotic cell death in cultured retinal endothelial cells but not pericytes: Association with decreased expression of p21waf1/cip1

✍ Qi Yan; E. Helene Sage 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 392 KB 👁 1 views

Transforming growth factor-␤1 (TGF-␤1) regulates a variety of cellular functions. In several types of cells, for example, it acts as a growth inhibitor and an inducer of apoptotic cell death. Although one of the important modulators in retinal vascular development and retinal neovascularization, the