2052 Neoadjuvant chemotherapy and radiotherapy for large soft tissue sarcomas
β Scribed by Ira J. Spiro; Herman Suit; Dempsey Springfield; Henry Mankin; Candace Jennings; Andrew Rosenberg; David Harmon
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 76 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0360-3016
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Despite advances in surgery and radiotherapy, patients continue to die from soft tissue sarcoma. An editorial is offered that discusses the impact of continued research into these challenging cancers.
A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment #1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1-5;
## Background: Downstaging of large soft tissue sarcomas can be accomplished by the use of neoadjuvant chemotherapy (neoct). the authors tested the hypothesis that radiographic response to neoct predicts improved local control and survival. ## Methods: The authors reviewed the medical records of
## Abstract ## BACKGROUND. The authors studied a doseβintense regimen of epirubicin and ifosfamide with hypofractionated preoperative radiotherapy for highβrisk soft tissue sarcomas. The primary objective was estimation of the rate of β₯95% pathologic necrosis. ## METHODS. Twentyβfive patients wi