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202. Brazilian Coral Snake Phospholipases A2 Induce Neuronal Death in Primary Cultures of Hippocampal Neurons

✍ Scribed by Nathalia Delazeri de Carvalho; Raphael Caio Tamborelli Garcia; Ivo Lebrun; Durvanei Augusto Maria; Silvia Carneiro; Solange Castro Afeche; Maria Regina Lopes Sandoval


Book ID
113934469
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
50 KB
Volume
60
Category
Article
ISSN
0041-0101

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Secreted phospholipase A2 potentiates gl
✍ Mark A. DeCoster; Gerard Lambeau; Michel Lazdunski; Nicolas G. Bazan πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 762 KB

## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamate‐induced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe