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20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation

✍ Scribed by Dmitry S. Trenin; Vladimir V. Volodin

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
80 KB
Volume
41
Category
Article
ISSN
0739-4462

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✦ Synopsis

20-hydroxyecdysone (1 mM) was found to activate in vitro Tcell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho-immunomodulator 1-oxy-4-oxoadamantane (1 mM) and to exceed the effects of the thymomimetic agent levamisol (1 mM). In addition, 20-hydroxyecdysone (1 mM) was also revealed to modulate the fluoride-stimulated respiratory burst of human neutrophils in the same manner as water soluble antioxidants. Arch. Insect Biochem. Physiol. 41:156-161, 1999.

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