2-Trifluormethyl-substituierte Aminosäuren, 19. 2-Trifluormethylaminosäureester, Bausteine für Trifluormethyl-substituierte Harnstoff-, Thioharnstoff-Derivate und andere potentielle Wirkstrukturen
✍ Scribed by Burger, Klaus ;Schierlinger, Christian ;Hollweck, Wolfgang ;Mütze, Kerstin
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 833 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
2‐Trifluoromethyl‐Substituted Amino Acids, 19. – 2‐Trifluoromethyl α‐Amino Acid Esters, Building Blocks for Trifluoromethyl‐Substituted Ureas, Thioureas and Other Potential Biological Active Structures
The preparative value of trifluoromethyl‐substituted building blocks increases with the number of additional functionalities present. 2‐Trifluoromethyl α‐amino acid esters 2 represent readily available starting materials, excellently suited for the introduction of the biologically interesting trifluoromethyl group into a variety of classes of compounds, like ureas 4 and thioureas, acylureas 5 and acylthioureas 12, imidazolidin‐2,4‐diones 8 and imidazolidin‐4‐on‐2‐thiones 11 as well as 2‐isocyanatoalkanoic acids 13. Via the latter Fmoc‐2‐trifluoromethyl α‐amino acid 16a can be readily prepared. magnified image