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2-(Tributylstannyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-indole: Synthesis and use as a 1H-indol-2-yl-anion equivalent

✍ Scribed by Giovanni Palmisano; Marco Santagostino


Publisher
John Wiley and Sons
Year
1993
Tongue
German
Weight
648 KB
Volume
76
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Pd‐Catalyzed reaction of 2‐(tributylstannyl)‐1‐{[2‐(trimethylsilyl)ethoxy]methyl}‐1__H__‐indole (5) with a variety of aryl, heteroaryl, vinyl, and allyl halides provides an efficient entry to the corresponding cross‐coupled products (see Table).


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Regiospecific synthesis of 5-(1H-indol-2
✍ Reddeppareddy Dandu; Ming Tao; Kurt A. Josef; Edward R. Bacon; Robert L. Hudkins 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 286 KB

## Abstract magnified image A regiospecific approach to each __N__‐methyl‐5‐(1__H__‐indol‐2‐yl)‐6,7‐dihydro‐2__H__‐indazole isomer is reported. The 1‐methyl isomer **1** was prepared from 5‐bromo‐1‐methyl‐6,7‐dihydro‐1__H__‐indazole **3** and indole‐2‐boronate **5** by palladium catalyzed Suzuki c