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2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation

✍ Scribed by Anna Palumbo; Marco d’Ischia; Fernando A Cioffi


Book ID
117102445
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
102 KB
Volume
485
Category
Article
ISSN
0014-5793

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN