2-SubstitutedN-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3adenosine receptors
โ Scribed by K.-N. Klotz; E. Camaioni; R. Volpini; S. Kachler; S. Vittori; G. Cristalli
- Book ID
- 105878451
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 105 KB
- Volume
- 360
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The structure-activity relationships (SAR) of alkylxanthine derivatives as antagonists at the recombinant human adenosine receptors were explored in order to identify selective antagonists of A 2B receptors. The effects of lengthening alkyl substituents from methyl to butyl at 1-and 3-positions and
A series of phenyl-substituted N 6 -phenyladenosines and N 6 -phenyl-5โฒ-N-ethylcarboxamidoadenosines were synthesized and tested at adenosine receptor subtypes. EC 50 values were determined for cyclic AMP production in CHO cells expressing human A 2B receptors. Binding affinities were determined for