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2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

✍ Scribed by Nagasawa, Herbert T.; Goon, David J. W.; Muldoon, William P.; Zera, Richard T.


Book ID
118028003
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
869 KB
Volume
27
Category
Article
ISSN
0022-2623

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## Abstract A series of double‐prodrugs of L‐cysteine, designed to release L‐cysteine in vivo and stimulate the biosynthesis of glutathione (GSH), were synthesized. To evaluate the hepatoprotective effectiveness of these double‐prodrugs, male Swiss‐Webster mice were administered acetaminophen (ACP)