2′-phosphodiesterase and 2′,5′-oligoadenylate synthetase activities in the lowest metazoans, sponge [porifera]
✍ Scribed by Emilie Saby; Jesper Buchhave Poulsen; Just Justesen; Merike Kelve; Maria Jesus Uriz
- Book ID
- 116309120
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 173 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0300-9084
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Treatment of NIH 3T3 cells with adenylate cyclase activator adrenaline (10(-6) M) or cAMP phosphodiesterase inhibitor theophylline (10(-3) M) was shown to lead to intracellular cAMP elevation followed by a 2.0-to 2.5-fold increase in the 2',5'-oligoadenylate synthetase activity. This process was blo
## Abstract Recently we established the presence of relatively high amounts of 2′‐5′oligoadenylates (2′‐5′A) and 2′‐5′oligoadenylate synthetase (2′‐5′A synthetase) in the marine sponge __Geodia cydonium.__ Here we determined by applying radioimmunoassay and high‐performance liquid chromatographical