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2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole Derivatives: New Potent Inhibitors of fMLP-Induced Neutrophil Chemotaxis.

✍ Scribed by Olga Bruno; Chiara Brullo; Francesco Bondavalli; Angelo Ranise; Silvia Schenone; Maria Sofia Falzarano; Katia Varani; Susanna Spisani

Publisher
John Wiley and Sons
Year
2007
Weight
27 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract magnified image An efficient and scalable synthesis of the potent CETP inhibitor, (2__R__,Ξ±__S__)‐3,4‐dihydro‐2‐[3‐(1,1,2,2‐tetrafluoroethoxy)phenyl]‐5‐[3‐(trifluoromethoxy)phenyl]‐α‐(trifluoromethyl)‐1(2__H__)‐quinolineethanol 1, is described. One of the important intermediates, tetrah