## Abstract 2‐Methoxyestradiol (2‐ME), a naturally occurring mammalian metabolite of 17β‐Estradiol (E~2~), induces cell death in osteosarcoma cells. To further understand the molecular mechanisms of action, we have investigated cell cycle progression in 2‐ME‐treated human osteosarcoma (MG63, SaOS‐2
2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest
✍ Scribed by Avudaiappan Maran; Kristen L. Shogren; Michaela Benedikt; Gobinda Sarkar; Russell T. Turner; Michael J. Yaszemski
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 23 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Abstract
The article to which this erratum refers was published in J. Cell. Biochem. 104: 1937–1945, 2008. © 2008 Wiley‐Liss, Inc.
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## Abstract 2‐Methoxyestradiol (2ME) is an endogenous metabolite with estrogen receptor‐independent anti‐tumor activity. The current study seeks to determine the mechanism of anti‐tumor activity of 2ME on human chondrosarcoma. 2ME caused a time‐ and dose‐dependent cytotoxity in chondrosarcoma cells
## Abstract 2‐Methoxyestradiol, a well‐known nonpolar endogenous metabolite of 17β‐estradiol, has been shown to selectively induce apoptosis in a number of cancer cell lines, but not in normal cells. The mechanism of 2‐methoxyestradiol‐induced apoptosis appears to vary considerably in different cel