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2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells?

✍ Scribed by Samar S. Azab; Salama A. Salama; Ashraf B. Abdel-Naim; Amani E. Khalifa; Ebtehal El-Demerdash; Ayman Al-Hendy

Book ID
106378074
Publisher
Springer US
Year
2008
Tongue
English
Weight
412 KB
Volume
113
Category
Article
ISSN
0167-6806

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2-Methoxyestradiol (2-ME 2 ) is a novel anticancer agent because of its ability to potentiate apoptotic cell death and inhibit cancer cell growth and angiogenesis. The modes of action of this agent, however, have not yet been fully elucidated. In our study, we have investigated whether 2-ME2 is able