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2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species–mitochondria pathway

✍ Scribed by Young-Min Han; Dae-Seop Shin; Yu-Jin Lee; Ismail Ahmed Ismail; Su-Hyung Hong; Dong Cho Han; Byoung-Mog Kwon

Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
886 KB
Volume
21
Category
Article
ISSN
0960-894X

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✦ Synopsis

a b s t r a c t 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI 50 value of 7 lM, while the parent compounds, HCA and curcumin, displayed GI 50 values of 12 and 30 lM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.

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