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2-hydroxy, 3,5-dibromo, 4-methoxyphenylacetamide. a dibromotyrosine metabolite from psammoposilla purpurea

✍ Scribed by Clifford W.J. Chang; Alfred J. Weinheimer


Book ID
104235708
Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
162 KB
Volume
18
Category
Article
ISSN
0040-4039

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✦ Synopsis


In our continuing study of anticancer agents in marine organisms,' we examined the sponge, Psammoposilla purpurea, which was collected from Enewetak in 1973.

The isopropanol-water (l/l, v/v) extract was worked up in the usual manner with preliminary fractionation using a trichloroethane (TCE)-methanol blend of the lypholyzed extract.


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tuo novel comtttumnta. biomnettcafly derived from dibrorotyrosine, uere obtained fron a sponge b~3YdD~ MXQPhQP1. The structure of aply8inadienc $ was cstabki8hed on the b88i8 of it8 rpectr8l propertic and by synthesis of & and it8 ,i8oMWS 2 8#kd @. The structure and absolute canfi~ration of the oxaz