A biomimetic approach towards the synthesis of pumiliotoxin C has been developed.The key transformation of enamine equivalent 8 to 2 was catalyzed by contact with alumina. Cyclized intermediate 2 was then reduced stereospecifically to the trans ----decahydroquinoline 11 or stereoselectively to the c
✦ LIBER ✦
2-cyano Δ3 piperideines X1: biomimetic synthesis of the ladybug alkaloids of the adaline series
✍ Scribed by D.H. Gnecco Medina; D.S. Grierson; H.-P. Husson
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 195 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The ladybug alkaloids 4 and 17 of the adaline series were synthesized via intra- -molecular Mannich reaction of the intermediate iminium-enols 2, generated from
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